Identifying (non-)coding RNAs and small peptides: Challenges and opportunities
نویسندگان
چکیده
منابع مشابه
Long non-coding RNAs and their significance in human diseases
Protein-coding genes account for only a small fraction of the human genome and most of the genomic sequences are transcriptionally silent, but recent observations indicate significant functional elements, including non-coding protein transcripts in the human genome. Long non-coding RNAs (lncRNAs) have been defined as transcripts of >200 nucleotides without protein-coding capacity that perform t...
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Analysis of the genomes of several higher eukaryotic organisms, including mouse and human, has reached the striking conclusion that the mammalian transcriptome is constituted in large part of non-protein-coding transcripts. Conversely, the number of protein-coding genes was initially at least overestimated. A growing number of studies report the involvement of non-coding transcripts in a large ...
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Experimental and computer-assisted approaches have led to the identification of hundreds of imprinted small RNA genes, mainly clustered in two chromosomal domains (human 15q11-->q13 and 14q32 loci). The genes are only detected in placental mammals and belong to the C/D RNA and microRNA gene families. These are small non-coding RNAs involved in RNA-guided post-transcriptional RNA modifications a...
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Non-coding RNAs (ncRNAs) were at first thought to be a non-specific noise. The vast majority of them have yet to be characterized thoroughly, but many of these ncRNAs are unlikely to represent transcriptional noise as a significant number have been shown to exhibit cell type-specific expression , localization to subcellular compartments , and association with human diseases (Wilusz et al., 2009...
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ژورنال
عنوان ژورنال: BioEssays
سال: 2014
ISSN: 0265-9247
DOI: 10.1002/bies.201400103